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The official website of Van Andel Institute
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    Scientists now have a powerful new resource for developing better treatments for common cancers of the esophagus, stomach, colon and rectum, collectively known as gastrointestinal (GI) adenocarcinomas. In all, these cancers claim more than 1.4 million lives annually across the globe. For more than 50 years, GI adenocarcinomas have largely defied therapeutic progress, stymying attempts...

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    The post Comprehensive atlas redefines gastrointestinal cancers appeared first on VAI.


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    As a kid, Dr. Bart Williams didn’t plan on being a scientist. That all changed after a summer spent working in a lab, the first step in a fruitful career that has contributed to advances in how we study cancer and shaped our understanding of bone diseases such as osteoarthritis. Now director of Van Andel...

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    The post Meet the scientist behind the science: Dr. Bart Williams appeared first on VAI.


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    What is cancer metastasis? Cancer metastasis refers to the spread of cancer cells beyond their original location, to other parts of the body. What causes metastasis? Metastasis occurs when cancer cells migrate from the primary tumor to another site via blood or lymph (more on the step-by-step process here). The resulting new tumor is the...

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    The post Explainer: What is cancer metastasis? appeared first on VAI.


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    Mahershala Ali, Kathy Bates, Katie Couric, Jennifer Garner, Tony Hale, Marg Helgenberger, Ed Helms, Ken Jeong, Marlee Matlin, Matthew McConaughey, Maria Menounos, Jillian Michaels, Trevor Noah, Dak Prescott, Italia Ricci,  Rob Riggle, Karla Souza, David Spade, Keith Urban, and Reese Witherspoon to appear in live one-hour event co-executive produced by Bradley Cooper  2018 telecast marks ten...

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    The post Stars rally together again for Stand Up To Cancer’s live broadcast on September 7 appeared first on VAI.


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    Each year, more than 10,000 children in the U.S. are diagnosed with cancer, a figure that has slowly but steadily risen over the past several decades. Today, thanks to improved care, more kids are beating cancer than ever before. Still, more research is desperately needed to root out the causes of pediatric cancers, which differ...

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    The post A Conversation About Pediatric Cancer Research and Treatment appeared first on VAI.


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    Pancreatic cancer is an aggressive, tough-to-treat disease in which malignant cells develop in the pancreas, a small gland located near the stomach that is responsible for producing hormones and digestive fluids. It is the third deadliest cancer in the U.S., claiming more than 40,000 lives each year. By 2020, it is expected to surpass colorectal...

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    The post Disease profile: Pancreatic cancer appeared first on VAI.


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    Last Friday was a day to remember, one that will affect lives for years to come. We were thrilled to be a part of the 2018 Stand Up To Cancer (SU2C) telecast, which raised a record-breaking $123 million for cancer research. The Institute has worked closely with Stand Up To Cancer since 2014, when it became...

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    The post That’s a wrap! Van Andel Research Institute featured in Stand Up To Cancer telecast appeared first on VAI.


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    Many of cancer’s long-buried secrets are now out in the open thanks to a collaborative effort to catalog the genetic switches that govern life The instructions for initiating and maintaining life are contained in DNA, a 6-foot-long, ladder-like molecule that determines every facet of our being from hair color to inherent risk for disease. Yet...

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    The post Large-scale cancer study locates “light switches” in the “dark” regions of the genome appeared first on VAI.


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  • 11/13/18--10:29: Connecting the genetic dots
  • Breast cancer is the most common cancer in women. Neurofibromatosis type 1 is a rare genetic disorder. A single gene may hold answers that could lead to new treatments for both. An aggressive breast cancer and a rare disease marked by benign tumors on the nerves and skin have a common genetic root, one that...

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    The post Connecting the genetic dots appeared first on VAI.


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    GRAND RAPIDS, Mich. (Nov. 28, 2018) — A powerful new biochemical platform is fueling the study of a family of enzymes that are promising targets for cancer treatment. Published today in Science Advances, the new method provides a high-resolution view of how these enzymes, called lysine methyltransferases, selectively mark proteins with chemical tags that alter their...

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    The post High-throughput platform enables scientists to map activity of an emerging class of cancer drug targets appeared first on VAI.